Muscarinic regulation of phospholipase D and its role in arachidonic acid release in rat submandibular acinar cells
β Scribed by H. C. Chung, N. Fleming
- Book ID
- 120903751
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 944 KB
- Volume
- 431
- Category
- Article
- ISSN
- 0031-6768
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Acetylcholine (ACh) caused repetitive transient CI-currents activated by intracellular Caz+ in single rat submandibular grand acinar cells. As the concentration of ACh increased the amplitude and the frequency of the transient CI-currents increased. These responses occurred also in the absence of ex
In a previous study, we have shown that endothelin-1 (ET-1) activates phospholipase D independently from protein kinase C in osteoblast-like MC3T3-E1 cells. It is well recognized that phosphatidylycholine hydrolysis by phospholipase D generates phosphatidic acid, which can be further degraded by pho