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Murine subrenal capsule assay: Prediction of chemoresponsiveness in head and neck cancer

✍ Scribed by William R. Panje; Kenneth J. Mccormick

Book ID
115043062
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
839 KB
Volume
99
Category
Article
ISSN
0023-852X

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Thirty-seven of 54 human squamous head and neck carcinomas were successfully grown as first transplant generation xenografts under the kidney capsule of conventional mice immunosuppressed by daily treatment with 60 mg/kg of cyclosporine. Of the 18 different tumors evaluated for chemosensitivity, 39%