✦ LIBER ✦

Multivariate linear mixed models for multiple outcomes

✍ Scribed by Mary Sammel; Xihong Lin; Louise Ryan

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 171 KB
Volume: 18
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(19990915/30)18:17/18<2479::aid-sim270>3.0.co;2-f

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✦ Synopsis

We propose a multivariate linear mixed (MLMM) for the analysis of multiple outcomes, which generalizes the latent variable model of Sammel and Ryan. The proposed model assumes a #exible correlation structure among the multiple outcomes, and allows a global test of the impact of exposure across outcomes. In contrast to the Sammel}Ryan model, the MLMM separates the mean and correlation parameters so that the mean estimation will remain reasonably robust even if the correlation is misspeci"ed. The model is applied to birth defects data, where continuous data on the size of infants who were exposed to anticonvulsant medications in utero are compared to controls.

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