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Multivariate analysis for histologic prognostic factors in soft tissue sarcomas

✍ Scribed by Masahiko Tsujimoto; Katsuyuki Aozasa; Takafumi Ueda; Yoshiyuki Morimura; Yoshio Komatsubara; Teruo Doi

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 428 KB
Volume: 62
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19880901)62:5<994::aid-cncr2820620526>3.0.co;2-4

No coin nor oath required. For personal study only.

✦ Synopsis

To investigate histologic prognostic factors in soft tissue sarcomas (STS), multivariate analysis was performed on 236 patients with complete clinical information. These included 141 males and 95 females with an age range from 1 to 85 years (median, 47.6 years). Histologically, malignant fibrous histiocytoma (33.5%) was the most common type followed by synovial sarcoma (11%), liposarcoma (lo%), rhabdomyosarcoma (7%), and leiom yosarcoma (7%). Monofactorial analysis revealed that sex, depth, location, histologic grade, cellularity, frequency of mitosis, and necrosis were significant prognostic factors. By multivariate analysis, only frequency of mitosis and depth of tumors were proved to be of prognostic significance. The prognostic importance of the frequency of mitosis as shown in previous and the present studies indicates that further investigation of the cell proliferation in patients with STS is required.

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