Multistep Synthesis Using Modular Flow Reactors: Bestmann–Ohira Reagent for the Formation of Alkynes and Triazoles

✍ Scribed by Ian R. Baxendale; Steven V. Ley; Andrew C. Mansfield; Christopher D. Smith

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 546 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200900970

✦ Synopsis

Abstract

Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three‐step oxidation/homologation/copper(I)‐catalyzed azide–alkyne cycloaddition sequence without isolation of intermediates (see scheme).magnified image