Multistep Synthesis Using Modular Flow R
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Ian R. Baxendale; Steven V. Ley; Andrew C. Mansfield; Christopher D. Smith
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Article
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2009
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John Wiley and Sons
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English
⚖ 546 KB
## Abstract **Multistep in flow:** The Seyferth–Gilbert reagent **1** has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole **3** from alcohol **2** in a three‐step oxidation/homologation/copper(I)‐catalyzed azide–alkyne