Multiple roles for CD4+ T cells in anti-tumor immune responses
β Scribed by Richard Kennedy; Esteban Celis
- Book ID
- 111248861
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 648 KB
- Volume
- 222
- Category
- Article
- ISSN
- 0105-2896
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While most of the focus in cancer immunology is on CD8+ cytotoxic T lymphocyte responses, recent evidence indicates that CD4+ T cells are an equally critical component of the antitumor immune response. Successful immunity to cancer will therefore require activation of tumor-specific CD4+ T cells. Tu
## Abstract TNFRSF25 is a member of the TNF receptor superfamily (TNFRSF) that binds to the TNFβlike protein TL1A. Although recent studies have demonstrated a role for TNFRSF25 in regulating CD4^+^ Tβcell responses, it remains to be determined if TNFRSF25 functions as a costimulatory receptor for C