✦ LIBER ✦

Multiple Regression Analysis Suggests Motifs for Class II MHC Binding

✍ Scribed by Ronna R. Mallios

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 226 KB
Volume: 166
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.1994.1015

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✦ Synopsis

Multiple regression analysis is utilized to predict peptides that bind major histocompatibility complex (MHC) class II molecules of the (d) haplotype. The predictor variables, obtained from the primary sequence of protein fragments, include pairs of amino acid residues separated by zero to seven intervening residues. The resulting models demonstrate strong predictive validity, and have interpretations in accordance with recent discoveries regarding the binding mechanisms of class I MHC molecules.

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