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Multiple neoplasms in two siblings with a variant form of Fanconi's anemia

โœ Scribed by Gregory Sarna; Peter Tomasulo; Michael J. Lotz; Joseph F. Bubinak; N. Raphael Shulman; Seymour Perry

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
477 KB
Volume
36
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

Two siblings with a variant form of Fanconi's anemia developed multiple neoplasms after prolonged survival and treatment with androgens. One of the siblings developed two separate oral squamous cell carcinomata, and the other developed acute leukemia and hepatoma. Androgens may have had a carcinogenic role in the appearance of the hepatic neoplasm. There is an increased incidence of neoplasm associated with Fanconi's anemia. This may be related to frequent spontaneous chromosomal aberrations and/or to increased cellular susceptibility to viral transformation.

Cancer 36

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