Multiple Myeloma

✍ Scribed by Robert A. Kyle, David P. Steensma (auth.), Thomas Moehler, Hartmut Goldschmidt (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2011
• Tongue: English
• Leaves: 364
• Series: Recent Results in Cancer Research 183
• Edition: 1
• Category: Library

✦ Synopsis

Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy. In particular, the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide means that multiple myeloma now stands at the forefront of advances in oncology drug development. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.

✦ Table of Contents

Front Matter....Pages i-xxiii
Front Matter....Pages 1-1
History of Multiple Myeloma....Pages 3-23
Epidemiology of Multiple Myeloma....Pages 25-35
Front Matter....Pages 37-37
Molecular Pathogenesis of Multiple Myeloma: Chromosomal Aberrations, Changes in Gene Expression, Cytokine Networks, and the Bone Marrow Microenvironment....Pages 39-86
Angiogenesis and Vasculogenesis in Multiple Myeloma: Role of Inflammatory Cells....Pages 87-95
Immunology and Immunotherapeutic Approaches in Multiple Myeloma....Pages 97-109
Front Matter....Pages 111-111
Monoclonal Gammopathy and Smoldering Multiple Myeloma: Diagnosis, Staging, Prognosis, Management....Pages 113-131
Imaging in Multiple Myeloma....Pages 133-147
Front Matter....Pages 149-149
Novel Drugs in Myeloma: Harnessing Tumour Biology to Treat Myeloma....Pages 151-187
Firstline Treatment and Maintenance in Newly Diagnosed Multiple Myeloma Patients....Pages 189-206
High-Dose Therapy and Autologous Peripheral Blood Stem Cell Transplantation in Patients with Multiple Myeloma....Pages 207-238
Therapy of Relapsed and Refractory Multiple Myeloma....Pages 239-271
Allogeneic Transplantation in Multiple Myeloma....Pages 273-284
Radiotherapy....Pages 285-291
Osteoplastic Procedures for the Treatment of Vertebral Complications in Multiple Myeloma Patients....Pages 293-306
Supportive Therapy in Multiple Myeloma....Pages 307-333
Back Matter....Pages 335-339

✦ Subjects

Oncology; Hematology; Cancer Research