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Multiple malformation syndrome following fluconazole use in pregnancy: Report of an additional patient

✍ Scribed by Aleck, Kyrieckos A.; Bartley, Douglas L.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 24 KB
Volume: 72
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19971031)72:3<253::aid-ajmg1>3.0.co;2-s

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✦ Synopsis

We report on a patient with malformations following long-term and high-dose maternal fluconazole use during pregnancy. The patient had exorbitism, a large pear-shaped nose, ''dysplastic'' ears, and radiohumeral synostosis. He is similar to three previously reported patients with in utero exposure to fluconazole and also shares some characteristics with the Antley-Bixler syndrome. The four fluconazole-exposed and malformed infants are compared with one another and with the Antley-Bixler syndrome. We conclude that fluconazole is a teratogen and results in a specific pattern of malformations following first trimester use. Am.

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