Multiple karyotypic rearrangements, including t(X;18)(p11;q11), in a fibrosarcoma
✍ Scribed by Nils Mandahl; Sverre Heim; Kristina Arheden; Anders Rydholm; Helena Willén; Felix Mitelman
- Book ID
- 119103926
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 636 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0165-4608
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## Abstract The first case of synovial sarcoma in a patient with Turner's syndrome (45,X) is reported. Cytogenetic analysis of the tumor cells showed that the only X chromosome was involved in the t(X;18)(p11;q11) characteristic of synovial sarcoma.
The initial cytogenetic analysis of a biphasic synovial sarcoma showed an apparently normal karyotype. After FISH using chromosome X-and 18-specific probes and RT-PCR using SYT-and SSX-specific primer sets, a cryptic synovial sarcomaassociated t(X;18)(p11;q11) could be revealed. The ''masked'' natur