✦ LIBER ✦

Multiple genetic abnormalities of 11p15 in Wilms' tumor

✍ Scribed by Feinberg, Andrew P.

Book ID: 102647355
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 665 KB
Volume: 27
Category: Article
ISSN: 0098-1532
DOI: 10.1002/(sici)1096-911x(199611)27:5<484::aid-mpo16>3.0.co;2-a

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✦ Synopsis

Wilms' tumor has served as a model of multiple genetic alterations in childhood cancer. This review summarizes work in our laboratory identifying several of these alterations. These include the localization to 11 p l 5 of an embryonal tumor suppressor gene and at least one gene for Beckwith-Wiedemann syndrome, which predisposes to Wilms' tumor; as well as a novel mutational mechanism in man, loss of imprinting.

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