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Multiple-dose kinetics of oral anticoagulants: Methods of analysis and optimized dosing

✍ Scribed by Theofanis G. Theofanous; Ronald G. Barile

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
603 KB
Volume
62
Category
Article
ISSN
0022-3549

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✦ Synopsis

A mathematical technique for estimating the kinetic parameters that control patient response to oral anticoagulant administration is presented. The technique utilizes routinely obtained and recorded data such as anticoagulant dose regimen and prothrombin times. It is possible to apply during any stage of therapy and to gain predictive capability from data covering the measured response over a minimum period of 2 days. The applicability of the technique is demonstrated by direct comparison with two actual patient records.

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