Deletions in the mitochondrial DNA (mtDNA) of Balb/c mouse cerebrums, resembling deletions found in elderly humans or in patients with certain disorders, were detected by PCR. Analysis was carried out on mice of various ages and on mice in which the bilateral common carotid arteries had been incompl
β¦ LIBER β¦
Multiple Deletions in Mitochondrial DNA Are Present in Senescent Mouse Brain
β Scribed by J.Y. Brossas; E. Barreau; Y. Courtois; J. Treton
- Book ID
- 115575011
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 346 KB
- Volume
- 202
- Category
- Article
- ISSN
- 0006-291X
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## Abstract We report a patient with an autosomal dominant chronic progressive external ophthalmoplegia phenotype associated with multiple mtDNA deletions in muscle from a family in which linkage analysis excluded mutations in DNA polymerase Ξ³ (POLG), adenine nucleotide translocase (ANTβ1) or C10or