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Multiple binding sites for nicotine receptor antagonists in inhibiting [3H](−)-nicotine binding in rat cortex

✍ Scribed by Richard Loiacono; Jenny Stephenson; Joanne Stevenson; Fred Mitchelson


Book ID
116037551
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
608 KB
Volume
32
Category
Article
ISSN
0028-3908

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The supernatant obtained from mouse brain homogenates contains material that inhibits the saturable binding of [3H]nicotine in mouse cerebral cortex. This inhibitory material was further purified by heat denaturation, ultrafiltration through an Amicon PM-10 membrane filter, and gel chromatography on