๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Multiple activation of chloroform in hepatic microsomes from uninduced B6C3F1 mice

โœ Scribed by Emanuela Testai; Stefano Di Marzio; Luciano Vittozzi


Book ID
113207461
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
677 KB
Volume
104
Category
Article
ISSN
0041-008X

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Multiple activation of chloroform in kid
โœ Ade, Paola ;Guastadisegni, Cecilia ;Testai, Emanuela ;Vittozzi, Luciano ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 616 KB

Microsomes from the renal cortex of DBA/2J mice can metabolize chloroform through oxidative and reductive pathways, similar to hepatic microsomes. The oxidative or reductive nature of CHC13 activation is strictly dependent on the oxygenation of the incubation mixture, as indicated by the formation

Toxicokinetics of bromodichloroacetate i
โœ J. L. Merdink; R. J. Bull; I. R. Schultz ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 60 KB

## Abstract The oral and i.v. elimination kinetics were investigated for bromodichloroacetate (BDCA), a haloacetate found in drinking water. The BDCA was administered at a dose of 5, 20 and 100 mg kg^โˆ’1^ to B6C3F1 mice and appears to distribute to the total body water with a mean volume of distribu

Long-term mutagenicity studies with chlo
โœ Byron E. Butterworth; Michael V. Templin; Alexander A. Constan; Catherine S. Spr ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 161 KB ๐Ÿ‘ 2 views

The weight of evidence indicates that chloroform then held until analysis 10, 30, 90, and 180 days induces cancer in the female B6C3F 1 mouse liver postexposure. Livers from DMN-treated mice exhibvia a nongenotoxic-cytotoxic mode of action. How-ited a dose-related 2-to 5-fold increase over control e