Multinuclear NMR studies and the kinetics of formation of platinum(II)-adenine nucleotide complexes
β Scribed by Bose, Rathindra N.; Cornelius, Richard D.; Viola, Ronald E.
- Book ID
- 111888628
- Publisher
- American Chemical Society
- Year
- 1986
- Tongue
- English
- Weight
- 799 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0002-7863
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The formation of complexes of Co(I1) with adenosine monophosphoric (AMP) and adenosine diphosphoric (ADP) anions have been studied by pH-stat and pH variable potentiometry and also by calorimetry. The existence. of complexes of type ML (CoAMP and CoADP-), MHL (CoHADP) and ML2 [Co(ADP)z-] is in good
## Abstract Platinum nitroimidazole complexes are potentially useful for sensitizing tumour cells towards radiation damage. We have studied reactions of __cis__β[Pt(II)(MNZ)~2~Cl~2~], where MNZ is 1β(2β²βhydroxyethyl)β2βmethylβ5βnitroimidazole (metronidazole), with guanosine monophosphate (5β²βGMP) a