Multinuclear MR studies of Platinum(II) nitroimidazole complexes: 15N-labelling and reactions with nucleotides

✍ Scribed by Fiona M. Macdonald; Peter J. Sadler

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 719 KB
• Volume: 29
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1260291312

✦ Synopsis

Abstract

Platinum nitroimidazole complexes are potentially useful for sensitizing tumour cells towards radiation damage. We have studied reactions of cis‐[Pt(II)(MNZ)~2~Cl~2~], where MNZ is 1‐(2′‐hydroxyethyl)‐2‐methyl‐5‐nitroimidazole (metronidazole), with guanosine monophosphate (5′‐GMP) and the oligonucleotides GpC, GpG and d(GpCpGpC) using ^1^H NMR spectroscopy. The complex [Pt(MNZ)~2~(5′‐GMP)~2~]Cl~2~ · 7H~2~O was isolated and characterized. Novel syntheses of cis‐ and trans‐[Pt(^15^N‐DMZ)~2~Cl~2~], where DMZ is 1,2‐dimethyl‐5‐nitroimidazole (dimetridazole), and NMR spectra of ^15^N‐enriched intermediates in the ligand synthesis, and of these complexes are discussed. Reactions of the enriched cis complex with 5′‐GMP were investigated by NMR spectroscopy.