## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Multinuclear NMR and Kinetic Analysis of DNA Interstrand Cross-Link Formation
β Scribed by Ding, Hui; Majumdar, Ananya; Tolman, Joel R.; Greenberg, Marc M.
- Book ID
- 126822459
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 1002 KB
- Volume
- 130
- Category
- Article
- ISSN
- 0002-7863
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Methylglyoxal (MG) , a dietary mutagen, is present in various frequently consumed beverages and foods and in cigarette smoke. A combination of S, nuclease hydrolysis and alkaline unwinding assay was used to demonstrate the formation of single-strand breaks and interstrand cross-links in DNA upon tr
## Abstract Interstrand crossβlinks (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic crossβlinking agents are well established in clinical use, and numero