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Hypoxia-Selective DNA Interstrand Cross-Link Formation by Two Modified Nucleosides

โœ Scribed by Dr. Yunyan Kuang; Dr. Huabing Sun; Dr. J. Craig Blain; Prof. Xiaohua Peng


Book ID
115551641
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
430 KB
Volume
18
Category
Article
ISSN
0947-6539

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Methylglyoxal (MG) , a dietary mutagen, is present in various frequently consumed beverages and foods and in cigarette smoke. A combination of S, nuclease hydrolysis and alkaline unwinding assay was used to demonstrate the formation of single-strand breaks and interstrand cross-links in DNA upon tr