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Multifunctional Role of Matrix Metalloproteinases in Multiple Myeloma: A Study in the 5T2MM Mouse Model

✍ Scribed by Els Van Valckenborgh; Peter I. Croucher; Hendrik De Raeve; Chris Carron; Evy De Leenheer; Sylvia Blacher; Laetitia Devy; Agnès Noël; Elke De Bruyne; Kewal Asosingh; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken

Book ID: 117021614
Publisher: American Society for Investigative Pathology
Year: 2004
Tongue: English
Weight: 827 KB
Volume: 165
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63349-4

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## Abstract During the last decade, a central role for insulin‐like growth factor 1 (IGF‐1) in the pathophysiology of multiple myeloma (MM) has been well established. IGF‐I provided by the tumor–microenvironment interaction may directly and indirectly facilitate the migration, survival and expansio