Increased bone remodeling due to ovariectomy dramatically increases tumoral growth in the 5T2 multiple myeloma mouse model

Targeting the IGF-1R using picropodophyl

Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: Beneficial effects on tumor growth, angiogenesis, bone disease and survival

✍ Eline Menu; Helena Jernberg-Wiklund; Hendrik De Raeve; Evy De Leenheer; Les Coul 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 267 KB 👁 1 views

## Abstract During the last decade, a central role for insulin‐like growth factor 1 (IGF‐1) in the pathophysiology of multiple myeloma (MM) has been well established. IGF‐I provided by the tumor–microenvironment interaction may directly and indirectly facilitate the migration, survival and expansio