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Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

✍ Scribed by Austin Doyle, L; Ross, Douglas D

Book ID
110068023
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
271 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract Breast cancer resistance protein (BCRP/ABCG2) of an ATP‐binding cassette half‐transporter confers resistance against mitoxantrone and camptothecin derivatives of topotecan and irinotecan. Novobiocin, a coumermycin antibiotic, is known to enhance anticancer drug sensitivity of cancer cel