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Multidrug resistance (MDR1) gene in inflammatory bowel disease: A key player?

โœ Scribed by Gwo-Tzer Ho; Daniel R Gaya; Jack Satsangi

Book ID
110087320
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
261 KB
Volume
11
Category
Article
ISSN
1078-0998

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Multidrug resistance 1 gene polymorphism
Multidrug resistance 1 gene polymorphism and susceptibility to inflammatory bowel disease
โœ S. Ardizzone; G. Maconi; V. Bianchi; A. Russo; E. Colombo; A. Cassinotti; C. Pen ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 108 KB

Background: Several studies have evaluated the role of the multidrug resistance 1 gene (MDR1) polymorphism, which encodes the membrane-bound efflux transporter P-glycoprotein 170, in determining susceptibility to and disease behavior in inflammatory bowel disease (IBD), but with conflicting results.

Is there evidence to claim or deny assoc
Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease?
โœ Elias Zintzaras ๐Ÿ“‚ Article ๐Ÿ“… 2012 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 984 KB

Background: Inflammatory bowel disease (IBD) is a complex disease with a genetic background. Crohn's disease (CD) and ulcerative colitis (UC) are the two main types of IBD. There is indication that variants in the MDR1 gene are associated with development of IBD. However, the 20 published genetic as