𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat

✍ Scribed by Gerald U Denk; Carol J Soroka; Yasuaki Takeyama; Wen-Sheng Chen; John D Schuetz; James L Boyer


Book ID
116650226
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
718 KB
Volume
40
Category
Article
ISSN
0168-8278

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Down-regulation of the organic cation tr
✍ Gerald U. Denk; Carol J. Soroka; Albert Mennone; Hermann Koepsell; Ulrich Beuers πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 200 KB

The liver plays a major role in biotransformation and elimination of various therapeutic agents and xenobiotics, many of which are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1). Oct1 is expressed at the basolateral membranes of hepatocytes and proximal renal tubu

Zonal down-regulation and redistribution
✍ Coen C. Paulusma; M. J. Kothe; Conny T. Bakker; Piter J. Bosma; Irene van Bokhov πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 829 KB

We have studied regulation of the multidrug resistance protein 2 (mrp2) during bile duct ligation (BDL) in the rat. In hepatocytes isolated after 16, 48, and 72 hours of BDL, mrp2-mediated dinitrophenyl-glutathione (DNP-GS) transport was decreased to 65%, 33%, and 33% of control values, respectively