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Cellular localization and up-regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver

✍ Scribed by Carol J. Soroka; John M. Lee; Francesco Azzaroli; James L. Boyer


Book ID
111721467
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
910 KB
Volume
33
Category
Article
ISSN
0270-9139

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We have studied regulation of the multidrug resistance protein 2 (mrp2) during bile duct ligation (BDL) in the rat. In hepatocytes isolated after 16, 48, and 72 hours of BDL, mrp2-mediated dinitrophenyl-glutathione (DNP-GS) transport was decreased to 65%, 33%, and 33% of control values, respectively