Multidisciplinary Approaches to Cholinesterase Functions

✍ Scribed by Palmer Taylor (auth.), Avigdor Shafferman, Baruch Velan (eds.)

• Publisher: Springer US
• Year: 1992
• Tongue: English
• Leaves: 294
• Edition: 1
• Category: Library

✦ Synopsis

Molecular Polymorphism: Biosynthesis of the Molecular Forms of Acetylcholinesterase (J. Massoulie et al.). Molecular Organization of Recombinant Human Acetylcholinesterase (B. Velan et al.). Nematode Acetylcholinesterases (M. Arpagaus et al.). Structure Function Relationship: Three Dimensional Structure of Acetylcholinesterase (J.L. Sussman et al.) Structural Analysis of Acetylcholinesterase Ammonium Binding Sites (I. Schalk et al.). Structural Investigations of Acetylcholinesterase (F. Hucho et al.). Physiological Role and Clinical Applications: Factors Influencing Acetylcholinesterase Regulation in Slow and Fast Skeletal Muscles (J. Sketelj et al.). Towards a Functional Analysis of Cholinesterases in Neurogenesis (P.G. Layer). Acetylcholinesterase as a Modulatory Neuroprotein and its Influence on Motor Control (S.A. Greenfield). 28 additional articles. Index.

✦ Table of Contents

Front Matter....Pages i-xvi
Impact of Recombinant DNA Technology and Protein Structure Determination on Past and Future Studies on Acetylcholinesterase....Pages 1-15
Biosynthesis of the Molecular Forms of Acetylcholinesterase....Pages 17-24
Binding of Asymmetric (A l2 ) Acetylcholinesterase to C 2 Muscle Cells and to Cho Mutants Defective in Glycosaminoglycan Synthesis....Pages 25-32
Subunit Assembly and Glycosylation of Mammalian Brain Acetylcholinsterase....Pages 33-38
Molecular Organization of Recombinant Human Acetylcholinesterase....Pages 39-47
Expression and Refolding of Functional Human Butyrylcholinesterase from E. Coli ....Pages 49-52
Part 1: Genetic Variant of Human Acetylcholinesterase Part 2: SV-40 Transformed Cell Lines, for Example COS-1, but Not Parental Untransformed Cell Lines, Express Butyrylcholinesterase (BChE)....Pages 53-59
Heterogeneity of the Silent Phenotype of Human Butyrylcholinesterase - Identification of Eight New Mutations....Pages 61-64
Nematode Acetylcholinesterases: Several Genes and Molecular Forms of Their Products....Pages 65-74
Drosophila Acetylcholinesterase: Analysis of Structure and Sensitivity to Insecticides by In Vitro Mutagenesis and Expression....Pages 75-81
Altered Forms of Acetylcholinesterase in Insecticide-Resistant Houseflies (Musca Domestica) ....Pages 83-86
PCR Generated Homologous DNA Probes and Sequence for Acetylcholinesterase Genes in Insect Pests....Pages 87-90
Testicular Gene Amplification and Impaired BCHE Transcription Induced in Transgenic Mice by the Human BCHE Coding Sequence....Pages 91-94
Three Dimensional Structure of Acetylcholinesterase....Pages 95-107
Sequence Alignment of Esterases and Lipases Based on 3-D Structures of Two Members of This Family....Pages 109-116
Structural Analysis of Acetylcholinesterase Ammonium Binding Sites....Pages 117-120
Structural Investigations of the Acetylcholinesterase....Pages 121-130
Substrate-Selective Inhibition and Peripheral Site Labeling of Acetylcholinesterase by Platinum(Terpyridine)Chloride....Pages 131-139
Cryptic Catalysis and Cholinesterase Function....Pages 141-148
Influence of Ionic Composition of the Medium on Acetylcholinesterase Conformation....Pages 149-156
Molecular Dissection of Functional Domains in Human Cholinesterases Expressed in Microinjected Xenopus Oocytes....Pages 157-164
Acetylcholinesterase Catalysis - Protein Engineering Studies....Pages 165-175
Site-Directed Mutagenesis of Functional Residues in Torpedo Acetylcholinesterase....Pages 177-183
Structurally Important Residues in the Region Ser91 to Asn98 of Torpedo Acetylcholinesterase....Pages 185-188
A Model of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterase Indicates Differences in Specificity....Pages 189-194
Molecular Models for Human AChE and its Phosphonylation Products....Pages 195-199
Relationships Between Activity of Organophosphorus Inhibitors of Acetylcholinesterase and Accessibility of Phosphorus Atom as Estimated by Molecular Mechanics Calculations....Pages 201-207
Factors Influencing Acetylcholinesterase Regulation in Slow and Fast Skeletal Muscles....Pages 209-216
Compartmentalization of Acetylcholinesterase mRNA and Protein Expression in Skeletal Muscle in Vitro and in Vivo : Implications for Regulation at the Neuromuscular Junction....Pages 217-222
Towards a Functional Analysis of Cholinesterases in Neuro-Genesis: Histological, Molecular, and Regulatory Features of BCHE from Chicken Brain....Pages 223-231
Acetylcholinesterase as a Modulatory Neuroprotein and its Influence on Motor Control....Pages 233-242
Different Influence of Inhibitors on Acetylcholinesterase Molecular forms G1 and G4 Isolated from Alzheimer’s Disease and Control Brains....Pages 243-249
Acetylcholinesterase Inhibition by Novel Carbamates: A Kinetic and Nuclear Magnetic Resonance Study....Pages 251-259
Experimental Acetylcholinesterase Autoimmunity....Pages 261-268
Clinical Implications of Cholinesterase Aberrations in Syndromes of Hemopoietic Cell Division....Pages 269-276
Acetylcholinesterase: A Pretreatment Drug for Organophosphate Toxicity....Pages 277-284
Recommendations for Nomenclature in Cholinesterases....Pages 285-288
Back Matter....Pages 289-293

✦ Subjects

Pharmacology/Toxicology; Biochemistry, general; Neurosciences