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Multicomponent reaction design: a one-pot route to substituted di-O-acylglyceric acid amides from α-diazoketones

✍ Scribed by Lijun Fan; Ashley M. Adams; Bruce Ganem


Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
154 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis


A four-component assembly of substituted di-O-acylglyceric acid amides has been developed from a-diazoketones. The process involves copper-catalyzed reaction of the a-diazoketone with a carboxylic acid, and subsequent Passerini condensation of the in situ formed a-acyloxyketone.


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ChemInform Abstract: Multicomponent Reac
✍ Lijun Fan; Ashley M. Adams; Bruce Ganem 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 32 KB

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