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Multicolor fluorescence in situ hybridization analysis of a synovial sarcoma of the larynx with a t(X;18)(p11.2;q11.2) and trisomies 2 and 8

✍ Scribed by Károly Szuhai; Jeroen Knijnenburg; Marije Ijszenga; Hans J. Tanke; Rob J. Baatenburg de Jong; Pieter Bas Douwes Dekker; Carla Rosenberg; Pancras C.W. Hogendoorn


Book ID
113512393
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
421 KB
Volume
153
Category
Article
ISSN
0165-4608

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## Abstract A somatic cell hybrid containing the synovial sarcoma‐associated t(X;18)(p11.2;q11.2) derivative (der(X)) chromosome was used to characterize the translocation breakpoint region on the X chromosome. By using Southern hybridization of DNA from this der(X) hybrid in conjunction with Xp‐re

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Identification of the t(X;18)(p11.2;q11.2) and the fusion gene products, SYT-SSX1 and SYT-SSX2, associated with a high proportion of synovial sarcomas, has been shown to be a useful diagnostic aid. This study demonstrates the application of dual colour fluorescence in situ hybridization to paraffin-