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Multicentric Castleman's disease with an increased serum level of macrophage colony-stimulating factor

✍ Scribed by Lee, Muneyasu; Hirokawa, Makoto; Matuoka, Satoru; Hasegawa, Hitoshi; Nanjo, Hiroshi; Matsushima, Takashi; Imatani, Hideo; Miura, Akira B.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 32 KB
Volume: 54
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199704)54:4<321::aid-ajh11>3.0.co;2-e

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✦ Synopsis

We describe a 74-year-old patient with multicentric Castleman's disease (MCD) whose serum macrophage colony-stimulating factor level was elevated. Serum levels of tumor necrosis factor-␣ and interleukin 6 were also elevated at presentation, and they returned to normal levels after chemotherapy. Although the total serum cholesterol level was below normal on admission, it increased after chemotherapy. These results suggest that the activation of monocytes or macrophages may be involved in certain pathological phenomena in MCD. Am.

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