✦ LIBER ✦
Eosinophilia resulting from administration of recombinant granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in a patient with T-γ lymphoproliferative disease
✍ Scribed by R. Gonzales-Chambers; Dr. C. Rosenfeld; A. Winkelstein; L. Dameshek
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 217 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
✦ Synopsis
A therapeutic trial of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was attempted in a patient with neutropenia and frequent infections secondary to T-y lymphoproliferative disease (T-y LPD). During the 14 days of subcutaneous rhGM-CSF (500 kg/m2/day), the absolute eosinophil count increased from 0 to 9,455/pl. By contrast, the absolute neutrophil count decreased. Toxicity related to rhGM-CSF included arthralgia and nonspecific chest pain. The possible mechanism for the rhGM-CSF induced selective eosinophilia is discussed.