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Multicellular tumour spheroids derived from human brain tumours

✍ Scribed by DARLING, J; OKTAR, N; THOMAS, D

Book ID
122239854
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
452 KB
Volume
7
Category
Article
ISSN
0309-1651

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An experimental trial of cyclic nucleoti
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The effects of cyclic nucleotides, dibutyryl cyclic adenosine monophosphate and dibutyryl cyclic guanosine monophosphate (db-cAMP and db-cGMP), on the growth rate of multicellular tumour spheroids were evaluated by comparing the growth delay and colony forming efficiency in vitro. Multicellular tumo

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## Abstract Human tumour cells from surgical material were grown as multicellular spheroids. In 16 out of 20 cultures spheroids with a diameter of more than 250 ΞΌm could be observed. In 6 out of 20 cultures more than 30 spheroids with a diameter of at least 300 ΓΌm were obtained, __i.e.__ 30% of the