Modelling acidosis and the cell cycle in multicellular tumour spheroids
β Scribed by Marcus J. Tindall; Louise Dyson; Kieran Smallbone; Philip K. Maini
- Book ID
- 113758907
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 358 KB
- Volume
- 298
- Category
- Article
- ISSN
- 0022-5193
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In this paper a mathematical model is developed to describe the migration of labelled particles within a multicell spheroid. In the model, spatial variations in cell proliferation and death create an internal velocity field which leads to redistribution of the labelled and unlabelled cells. By apply
## Abstract Multicellular spheroids of the EMT6/Ca/VJAC mouse mammary tumour cell line have been used in an investigation of the effect of tumour geometry on the response of tumour cells to 3 cytotoxic drugs, adriamycin (ADM), nitrogen mustard (HN2) and CCNU. In addition to the inherent cellular dr