Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor
β Scribed by L.A. Kunz-Schughart
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 492 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1065-6995
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π SIMILAR VOLUMES
h~ vivo volume growth of two murine tumor cell lines was compared by mathematical modeling to their volume growth as multicellular spheroids. Fourteen deterministic mathematical models were studied. For one cell line, spheroid growth could be described by a model simpler than needed for description
Cells in the inner region of multicellular spheroids markedly reduce their oxygen consumption rate, presumably in response to their stressful microenvironment. To determine the mechanism behind this metabolic adaptation, we have investigated relative mitochondrial mass and mitochondrial function in
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