Tumor line dependent interactions of irradiation and cis-diamminedichloroplatinum in the multicellular tumor spheroid system

Involvement of the mitochondrion respira

Involvement of the mitochondrion respiratory chain in the synergy achieved by treatment of human ovarian carcinoma cell lines with both tumor necrosis factor-α and cis-diamminedichloroplatinum

✍ Ruchan Uslu; Benjamin Bonavida 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 668 KB

## BACKGROUND. Previous studies have demonstrated that treatment of human tumor cell lines with a combination of cis-diamminedichloroplatinum (CDDP) and tumor necrosis factor-a (TNF-a) results in additivelsynergistic cytotoxic effects and reverses tumor cell resistance to TNF drugs. Free radical i