Multi-faceted regulation of γ-glutamylcysteine synthetase

✍ Scribed by Syrus R. Soltaninassab; Konjeti R. Sekhar; Michael J. Meredith; Michael L. Freeman

• Book ID: 101261439
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 121 KB
• Volume: 182
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/(sici)1097-4652(200002)182:2<163::aid-jcp4>3.0.co;2-1

✦ Synopsis

Glutathione is an important antioxidant that is involved in numerous cellular activities. ␥-Glutamylcysteine synthetase (␥GCS) is a key regulatory enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein that belongs to a unique class of proteins that gain activity due to formation of a reversible disulfide bond. The two subunits of ␥GCS exhibit differential and coordinate transcription regulation. In addition, the subunits are regulated at the posttranscriptional and posttranslational levels. These various levels of regulation allow numerous stimuli to induce or inhibit activity.