Expression and Purification of Human γ-Glutamylcysteine Synthetase
✍ Scribed by Ila Misra; Owen W. Griffith
- Book ID
- 115645327
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 179 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1046-5928
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Gamma‐glutamylcysteine synthetase (γ‐GCS) is a heterodimer consisting of heavy (γ‐GCSh) and light (γ‐GCSl) subunits. γ‐GCS catalyzes the rate‐limiting __de novo__ biosynthesis of glutathione (GSH), an abundant physiological antioxidant that plays important roles for regulating oxidative
Glutathione is an important antioxidant that is involved in numerous cellular activities. ␥-Glutamylcysteine synthetase (␥GCS) is a key regulatory enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein that belongs to a unique class of proteins that gain activity due to fo