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Mucosal damage induced by preferential COX-1 and COX-2 inhibitors: Role of prostaglandins and inflammatory response

✍ Scribed by Isabel Villegas; Carmen La Casa; Catalina Alarcón de la Lastra; Virginia Motilva; Juan Manuel Herrerı́as; Marı́a José Martı́n

Book ID: 116717119
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 339 KB
Volume: 74
Category: Article
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2003.07.021

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## Abstract Macrophages crosstalk with oxidized low‐density lipoprotein (oxLDL), play a critical role in the initiation, progression, and subsequently stability of atherosclerotic plaques. Statins, inhibitors of HMG CoA (3‐hydroxy‐3‐methylglutaryl coenzyme A) reductase, reduce the expression of inf