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MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines

โœ Scribed by Bruce Acres; Vasso Apostolopoulos; Jean-Marc Balloul; Danny Wreschner; Pei-Xiang Xing; Dahlila Ali-Hadji; Nadine Bizouarne; Marie Paule Kieny; Ian F.C. McKenzie

Book ID
105744744
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
220 KB
Volume
48
Category
Article
ISSN
0340-7004

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C57BL/6 mice transgenic for human MUC1 (MUC1.Tg) have been developed to investigate the autoimmune consequences of producing MUC1 tumor immunity in an animal that expresses MUC1 as a self-protein on normal ductal epithelia. Previous work showed that MUC1.Tg mice challenged with MUC1-bearing syngenei