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A MUC1/IL-18 DNA vaccine induces anti-tumor immunity and increased survival in MUC1 transgenic mice

✍ Scribed by Linda A. Snyder; Theresa J. Goletz; George R. Gunn; Frank F. Shi; Michael C. Harris; Karyn Cochlin; Christine McCauley; Stephen G. McCarthy; Patrick J. Branigan; David M. Knight


Book ID
116958701
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
461 KB
Volume
24
Category
Article
ISSN
0264-410X

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## Abstract Tumor cells express tumor‐associated antigens (TAAs), which can serve as targets for the immune system. However, the majority of TAAs are overexpressed products of normal cellular genes; as such, self‐tolerance mechanisms have hindered their use for the induction of effective antitumor