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MS370 WATER EXTRACTS OF CINNAMON AND CLOVE EXHIBITS POTENT INHIBITION OF PROTEIN GLYCATION AND ANTI-ATHEROSCLEROTIC ACTIVITY IN VITRO, AND IN VIVO

✍ Scribed by Jin, S.-R.; Park, K.; Park, J.-H.; Jung, S.-H.; Cho, K.-H.

Book ID
118638872
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
82 KB
Volume
11
Category
Article
ISSN
1567-5688

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Analogues of staurosporine were synthesized and their ability to inhibit protein kinases was examined. Staurosporine is a potent but non-selective inhibitor of in vitro protein kinase C (PKC) activity (K5, 6.0 nn). The derivative CGP 41 25 I had reduced PKC activity with an IC,, of 50 nn but showed