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MRP-1/CD9 gene transduction downregulates Wnt signal pathways

✍ Scribed by Huang, Cheng-long; Liu, Dage; Masuya, Daiki; Kameyama, Kotaro; Nakashima, Takashi; Yokomise, Hiroyasu; Ueno, Masaki; Miyake, Masayuki

Book ID: 110069128
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 244 KB
Volume: 23
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1208063

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## Abstract Osteoprotegerin (OPG), a secreted member of the tumor necrosis receptor superfamily, is a potent inhibitor of osteoclast formation and bone resorption. Parathyroid hormone (PTH), a potent inducer of osteoclast formation, suppresses OPG mRNA expression in vitro and in vivo. To determine