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MRI measurement of liver regeneration in mice following partial hepatectomy

✍ Scribed by J.R. Garbow; M. Kataoka; M.W. Flye

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
278 KB
Volume
52
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Improvements in noninvasive imaging modalities are crucial for preoperative in vivo assessments of liver condition and potential for regeneration after liver resection for removal of liver tumors. To that end, an MRI study of liver regeneration in mice following partial hepatectomy is described and validated. Hepatic volumes were accurately measured from contrast-enhanced, gradient-echo images of the liver. Regeneration curves were constructed for a series of mice (N = 6) from a longitudinal MR study, with images collected 1, 2, 3, 4, 5, and 9 days following surgery. We validated the MR method by correlating serial MR-measured volumes with liver wet weight. The success of this method will enable future studies to better elucidate the factors that affect regeneration, and help to optimize the timing and dosing of chemotherapeutics to minimize their deleterious effects on liver regeneration.

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