The role of leukotriene (LT) on liver regeneration tion 1 and immune response 2-6 by a variety of mechaafter hepatectomy is still unknown. LTB 4 stagnates in nisms such as enhancement of leukocyte migration, dethe liver with obstructive jaundice, because LTB 4 is exgranulation of neutrophils, production of interleukincreted in the bile; therefore, LTB 4 may have an effect on 1, and activation of macrophages, natural killer cells, liver regeneration after hepatectomy with obstructive and cytotoxic T lymphocytes. However, the role of LTs jaundice. Release of obstructive jaundice and simultanein liver regeneration after hepatectomy is still unous 70% hepatectomy was performed in rats to study known. 7 the effect of 5-lipoxygenase inhibitor (AA-861) on liver LTB 4 is normally metabolized in the liver and exregeneration. Group 1 underwent hepatectomy with adcreted into the bile, 8 so it is thought that it accumulates ministration of 0.1 mL dimethyl sulfoxide (DMSO), group in obstructive jaundice and may possibly have an unfa-2 underwent hepatectomy with administration of AA-861 (20 mg/kg/d) dissolved in 0.1 mL DMSO, group 3 un-vorable effect on liver regeneration after hepatectomy. derwent hepatectomy with administration of AA-861 (40 Therefore, we presume that LTs may play an important mg/kg/d) dissolved in 0.1 mL DMSO, group 4 underwent role in liver injuries and that inhibition of 5-lipoxygenrelease of obstructive jaundice and hepatectomy with ase may be beneficial for liver regeneration.
administration of 0.1 mL DMSO, and group 5 underwent
Hepatectomy is often performed in the presence of relief of obstructive jaundice and hepatectomy with adobstructive jaundice when patients have cancer of bile ministration of AA-861 (20 mg/kg/d). DMSO or AA-861 duct at porta hepatis or gallbladder. 9,10 In the present was administered 24 hours before, during, and 24 hours study, the effect of a 5-lipoxygenase inhibitor on liver after hepatectomy in each group. Whole blood LTB 4 and regeneration after partial hepatectomy was evaluated serum alanine aminotransferase (ALT), total bilirubin, in normal and icteric rats that underwent decompresand bromodeoxyuridine labeling index (LI) were measured before and after hepatectomy. The LTB 4 level in-sion of obstructive jaundice with concurrent hepateccreased during obstructive jaundice and after hepatectomy.