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MRI-defined vascular depression: a review of the construct

✍ Scribed by Michelle E. Culang-Reinlieb; Lauren C. Johnert; Adam M. Brickman; David C. Steffens; Ernst Garcon; Joel R. Sneed

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
206 KB
Volume
26
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objective

To review the construct of MRI‐defined vascular depression and to examine the substantive and methodological issues that bear on its validity as a distinct subtype of depression in late life.

Design

Literature review.

Results

We identified three areas that are critical to establishing the validity of MRI‐defined vascular depression: (1) understanding and delineating the relationship between MRI hyperintensities, executive dysfunction, and antidepressant treatment outcome; (2) understanding the relationship between, and establishing the validity of, qualitative and quantitative approaches to the measurement of MRI hyperintensities (the primary feature of the proposed subtype); (3) establishing the clinical presentation and course of the subtype in the context of other late‐life disorders.

Conclusions

Despite considerable data supporting the validity of MRI‐defined vascular depression, there are a number of critical issues that remain, including establishing a causal relationship between cerebrovascular disease and late‐life depression, establishing consistent diagnostic criteria, determining the importance of lesion type and location, and understanding the course of the disorder. Copyright Β© 2010 John Wiley & Sons, Ltd.

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