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MR microscopy of lung airways with hyperpolarized 3He

✍ Scribed by X. Josette Chen; Mark S. Chawla; Laurence W. Hedlund; Harald E. Möller; James R. Macfall; G. Allan Johnson; Elaine G.

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
723 KB
Volume
39
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A technique using hyperpolarized (HP) ^3^He to image the small airways of the lung by using moderate flip angles and a short scanning period during early inspiration is demonstrated. Flip angles (α) ranging from 10–90° were used in guinea pig experiments with scanning during the entire inspiration period. A second series acquired data throughout a short window of the ventilatory cycle with α= 45°. The success of the animal studies has motivated implementation of similar imaging techniques in the clinical arena. Human studies involved imaging over the total inspiration period with α ≈︁ 10°. The first series of guinea pig experiments demonstrated that larger flip angles (50‐90°) destroy the magnetization before it reaches the smaller airways. At moderate flip angles (20‐40°), airway branching down to the fourth generation was apparent. Fifth‐order branchings were seen in the images of the second series. The trachea down to fourth generation pulmonary airway branching, along with some distal air spaces, was seen in the human lung images.

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