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MR Lymphography with a Lymphotropic T1-Type MR Contrast Agent: Gd-DTPA-PGM

✍ Scribed by Liliane Harika; Ralph Weissleder; Kirtland Poss; Claus Zimmer; Mikhail I. Papisov; Thomas J. Brady

Book ID
102952514
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
845 KB
Volume
33
Category
Article
ISSN
0740-3194

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✦ Synopsis

A model system of a paramagnetic lymphotropic MR contrast agent (Gd-DTPA labeled polyglucose associated macrocomplex, PGM) for T,-weighted MR imaging of lymph nodes in rats and rabbits was evaluated. Pharmacokinetic (tissue accumulation) and MR imaging data (optimal dose and timing parameters) were obtained in normal rats (n = 88) after subcutaneous (SC) injection of paramagnetic, radiolabeled [lll InIGd-DTPA-PGM. A rabbit model of lymph node metastases (n = 8) was ultimately used to demonstrate the potential of MR imaging with Gd-DTPA-PGM for nodal tumor detection. Maximum concentrations of Gd-DTPA-PGM were found in popliteal and paraaortic lymph nodes within 24 h after SC administration, and highest lymph node SNR values were obtained by MR imaging at this time point. The optimum imaging dose was 6-12 pmol Gdkg. Tumor-lymph node contrast increased from 0.0 ? 1.2 precontrast to 19.2 * 6.5 (spoiled gradient echo sequence, TR 50lTE 7Iflip angle Soo) postcontrast and conspicuity of nodal metastases was improved. Gd-DTPA-PGM accumulates in lymph nodes after SC administration and significantly enhances lymph node signal intensity of normal animals but not metastatic lymph nodes.

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