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MPTP- and Manganese-induced apoptosis in PC12 cells

✍ Scribed by M.S. Desole; L. Sciola; G. Fenu; S. Sircana; R. Migheli; R. Delogu


Book ID
119180151
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
135 KB
Volume
31
Category
Article
ISSN
1043-6618

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Our previous studies showed that S-adenosyl-methionine (SAM) induced Parkinson's disease-like changes in rat. It caused death to dopamine neurons in the substantia nigra, which appeared shrunken and fragmented, indicative of apoptosis-like changes (Charlton and Crowell [1995] Mol. Chem. Neuropathol.