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Ceramide induces apoptosis in PC12 cells

✍ Scribed by Perry J Hartfield; George C Mayne; Andrew W Murray


Book ID
117106972
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
534 KB
Volume
401
Category
Article
ISSN
0014-5793

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Our previous studies showed that S-adenosyl-methionine (SAM) induced Parkinson's disease-like changes in rat. It caused death to dopamine neurons in the substantia nigra, which appeared shrunken and fragmented, indicative of apoptosis-like changes (Charlton and Crowell [1995] Mol. Chem. Neuropathol.